Serum magnesium levels in healthy dogs submitted to the administration of cisplatin with fluid therapy

Article Sidebar

Main Article Content

Carlos Alfredo Calpa Oliva
Carlos Roberto Daleck
João Humberto Teotônio de Castro
Andrigo Barboza de Nardi

Abstract

Cisplatin is an antineoplastic drug that is used to treat carcinomas and osteosarcomas in dogs. However, it can cause kidney damage which in turn leads to the loss of electrolytes. Concentration of magnesium was evaluated in the blood serum of eight dogs that had undergone therapy with cisplatin. The dogs were divided into two groups. Group 1 was supply with cisplatin (70 mg/m2, iv) and to prevent nephrotoxcity, saline solution at 0.9% was administered (25 ml/kg/hour, iv in three hours). The animals in Group 2 were not supplied with cisplatin. There was no significant difference (P < 0.05) between the two groups and the results obtained indicated that the protocol used for Group 1 did not cause changes in the serum concentrations of magnesium. Therefore, it can be concluded that the administration of cisplatin does not cause variations if it is combined with the fluid therapy.
Keywords:
CISPLATIN FLUID THERAPY CHEMOTHERAPY MAGNESIUM ELECTROLYTES

Article Details

License

Creative Commons License
Veterinaria México OA by Facultad de Medicina Veterinaria y Zootecnia - Universidad Nacional Autónoma de México is licensed under a Creative Commons Attribution 4.0 International Licence.
Based on a work at http://www.revistas.unam.mx
  • All articles in Veterinaria México OA re published under the Creative Commons Attribution 4.0 Unported (CC-BY 4.0). With this license, authors retain copyright but allow any user to share, copy, distribute, transmit, adapt and make commercial use of the work, without needing to provide additional permission as long as appropriate attribution is made to the original author or source.
  • By using this license, all Veterinaria México OAarticles meet or exceed all funder and institutional requirements for being considered Open Access.
  • Authors cannot use copyrighted material within their article unless that material has also been made available under a similarly liberal license.