Effect of prostaglandin F2α administration during the first postpartum hours on the serum calcium concentration of dairy cows

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Eligio Gabriel Salgado-Hernández
Departamento de Patología, Sección Patología Clínica, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Av. Universidad 3000, Col. Cd. Universitaria, 04510 México, D.F., México
Jan Bouda
Departamento de Patología, Sección Patología Clínica, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Av. Universidad 3000, Col. Cd. Universitaria, 04510 México, D.F., México
Adolfo Aparicio-Cecilio-A
Departamento de Patología, Sección Patología Clínica, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Av. Universidad 3000, Col. Cd. Universitaria, 04510 México, D.F., México
Jaroslav Doubek
Department of Physiology, Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic
Francisco Hernany Velásquez-Forero
Laboratorio de Metabolismo Mineral y Óseo, Hospital Infantil de México “Federico Gómez” Dr. Márquez 162, Col. Doctores, Del. Cuauhtémoc, 06720, México, D.F., Mexico

Abstract

Veterinaria México OA
ISSN: 2448-6760

Cite this as:

  • Salgado-Hernández EG, Bouda J, Aparicio-Cecilio-A A, Doubek J, Velásquez-Forero FH. Effect of prostaglandin F2α administration during the first postpartum hours on the serum calcium concentration of dairy cows. Veterinaria México OA. 2014;1(2). doi: 10.21753/vmoa.1.2.337.
Subclinical hypocalcemia occurs frequently in dairy cows and predisposes them to reproductive pathologies. Prostaglandin F2α (PGF2α) improves uterine health and increases the level of serum calcitriol in other species. The aim of this study was to evaluate the effect of sodium cloprostenol on serum calcium, metabolites of vitamin D and reproductive variables. Eighty multiparous Holstein cows were selected and randomized into two groups. The cows in Group 1 (n = 38) were treated with 500 µg of I M sodium cloprostenol, a synthetic analog of PGF2α, at 1 and 48 h postpartum. Group 2 was the control group (n = 42). Blood samples were taken from 10 animals per group at 1, 3, 12, 24, 48 h and 7 d postcalving. The incidence of retained placenta, metritis and endometritis and the number of open days were recorded. The concentrations of Ca, P, Mg, calcidiol and calcitriol in the serum were evaluated using an analysis of variance for repeated measures design. The serum Ca concentration was increased up to normalized at day 7 in the PGF2α group compared with the level in the control group. PGF2α treatment increased the serum calcium concentration and reduced the number of open days, and thus, could be useful in preventing subclinical hypocalcemia and postpartum reproductive problems.

Figure 4. Cumulative percentage of conception in dairy cows treated with 500 µg of sodium cloprostenol at 1 and 48 h postpartum (n = 38) and in controls (n = 42). The curves are significantly different (P = 0.02), as determined using the Log Rank test.
Keywords:
Prostaglandin F2α Subclinical hypocalcemia Calcitriol Postpartum dairy cow.
DOI: https://doi.org/10.21753/vmoa.1.2.337

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