Canine lymphoma: Pathological and clinical characteristics of patients treated at a referral hospital

Diana Sánchez, Rogelio Sánchez-Verin, Hortensia Corona, Angelina Gutiérrez, Luis Núñez-Ochoa, Jesús Paredes, Gabriela Cesarman-Maus


Veterinaria México OA
ISSN: 2448-6760

Cite this as:

  • Sánchez D, Sánchez-Verin R, Corona H, Gutiérrez A, Núñez-Ochoa L, Paredes J, Cesarman-Maus G. Canine lymphoma: Pathological and clinical characteristics of patients treated at a referral hospital. Veterinaria México OA. 2019;(2). doi: 10.22201/fmvz.24486760e.2019.2.495.

Non-Hodgkin’s lymphomas are common canine cancers with variable demographic and clinical presentations. Their pathological characterization and treatment lag far behind those of humans. We describe consecutive lymphoma patients detected over a one-year period at the National Autonomous University of Mexico (UNAM). Of 4,512 dogs: 220 (4.9%) had a cancer diagnosis, of which 27 (0.6%) had lymphoma (12% of cancer patients). We found an association with Miniature Schnauzers, which represented 18.5% (5/27) of lymphoma patients, but it was only 6.4% (288/4,512) of the dogs studied in this time period (p < 0.011). Miniature Schnauzers and mongrels together constituted nearly half of lymphoma cases. Mean age at diagnosis was 7.5 years (3-14), with a female to male ratio of 1.7:1. We found no correlation between lymphoma and castration status. Most patients presented nodal involvement (80%), were in advanced stages III/IV (90%) and had B-cell versus T-cell tumors (64%/36%). Only two histopathological patterns were seen, both with diffuse nodal-replacement by large immunoblast and/or centroblast-like cells; one having numerous tingible-body macrophages which are suggestive of a high proliferative rate. Chemotherapy was given to 15 patients (65%) with an overall response of 73% (3 complete responses/8 partial responses) and a mean overall survival of 219 days (4-586; SD±185). One cutaneous lymphoma-patient achieved partial response (PR) with lomustine/prednisone, and treatment was still ongoing at 548 days. Earlier diagnosis, better lymphoma subtype distinction, and specific curative treatments are needed.

Figure 1. The only two histopathological patterns observed in canine lymphoma biopsies. Two morphological patterns were observed by hematoxylin and eosin staining. The first with diffuse susbstitution of the lymph node architecture by large cells resembling inmunoblasts and scarce centroblasts A (10×) and B (40×). The second with a similar diffuse nodal replacement by large centroblast-like cells with disperse immunoblasts and numerous tingible body marhophages giving a starry sky-like appearance C (10×) and D (40×).


dog, canine, cancer, lymphoma.

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