Anesthetic evaluation of a novel phospholipid-free 1% propofol microemulsion formulation in dogs

Abstract

Veterinaria México OA
ISSN: 2448-6760

Cite this as:

• Aquino I, Gutiérrez-Blanco E, Ocampo L, Gutiérrez L, Bernard-Bernard MJ, Sumano H. Anesthetic evaluation of a novel phospholipid-free 1% propofol microemulsion formulation in dogs. VetMéxOA. 2019;6(3). doi: 10.22201/fmvz.24486760e.2019.3.654.

A novel four-week stable experimental formulation of propofol lacking phospholipids (PMICRO) was assessed as an anesthetic agent in dogs and compared to the customary preparation of propofol that contains phospholipids (PMACRO). Forty healthy mixed-breed dogs were included in this study and randomly assigned (blocking by sex and age), to receive 5 mg/kg of one of these two pharmaceutical propofol preparations, by intravenous injection. Basal and post anesthetic blood biochemical parameters were measured. Also, cardiovascular and respiratory rates were recorded. Onset, duration and recovery from anesthesia, were documented as well. Overall, IV administration of PMICRO induces a short duration anesthesia with rapid recovery in a similar manner to anesthesia achieved with the customary propofol preparation (PMACRO). Because PMICRO lacks phospholipids, it may allow a longer storage time, decreasing the likeliness of accidental administration of contaminated propofol.

Figure 1. Particle size (nm) of a phospholipid-free 1% propofol microemulsion (PMICRO) diluted with either sterile 0.89% saline solution (SS) or 5% glucose solution (D5W) at different concentrations. Particle size was measured 5 min after dilution.